| Peer-Reviewed

Research Progress of Exosome Non-coding RNA in Cancer

Received: 26 January 2019     Published: 8 March 2019
Views:       Downloads:
Abstract

Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.

Published in Science Discovery (Volume 7, Issue 1)
DOI 10.11648/j.sd.20190701.13
Page(s) 13-17
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Exosome, Cancer, Non-coding RNA

References
[1] Sund M, Kalluri R. Tumor stroma derived biomarkers in cancer [J]. Cancer Metastasis Rev, 2009, 28(1-2):177-183.
[2] Bullock MD, Silva AM, Kanlikilicer-Unaldi P, Filant J, Rashed MH, Sood AK, Lopez-Berestein G, Calin GA. Exosomal Non-Coding RNAs: Diagnostic, Prognostic and Therapeutic Applications in Cancer[J]. Noncoding RNA, 2015, 1(1):53-68.
[3] Grimaldi A, Zarone MR, Irace C, Zappavigna S, Lombardi A, Kawasaki H, Caraglia M, Misso G. Non-coding RNAs as a new dawn in tumor diagnosis [J]. Semin Cell Dev Biol, 2018, 78:37-50.
[4] Yang S, Li X. Recent advances in extracellular vesicles enriched with non-coding RNAs related to cancers[J]. Genes & Diseases, 2018, 5(1):36-42.
[5] Skotland T, Sandvig K, Llorente A. Lipids in exosomes: Current knowledge and the way forward [J]. Prog Lipid Res, 2017, 66:30-41.
[6] Mercer TR, Mattick JS. Structure and function of long noncoding RNAs in epigenetic regulation [J]. Nat Struct Mol Biol, 2013, 20(3):300-307.
[7] Yu S, Cao H, Shen B, Feng J. Tumor-derived exosomes in cancer progression and treatment failure [J]. Oncotarget, 2015, 6(35):37151-37168.
[8] Mathivanan S, Simpson RJ. ExoCarta: A compendium of exosomal proteins and RNA [J]. Proteomics, 2009, 9(21):4997-5000.
[9] Azmi AS, Bao B, Sarkar FH. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review [J]. Cancer Metastasis Rev, 2013, 32(3-4):623-642.
[10] Consortium EP. An integrated encyclopedia of DNA elements in the human genome [J]. Nature, 2012, 489(7414):57-74.
[11] 谢兆辉. 长非编码RNA在基因表达调节中的作用[J]. 生命的化学, 2010, 30(3):345-349.
[12] Milane L, Singh A, Mattheolabakis G, Suresh M, Amiji MM. Exosome mediated communication within the tumor microenvironment [J]. J Control Release, 2015, 219:278-294.
[13] DP B. MicroRNAs: genomics, biogenesis, mechanism, and function [J]. Cell Biol Int, 2004, 116(2):281-297.
[14] Ha M, Kim VN. Regulation of microRNA biogenesis[J]. Nat Rev Mol Cell Biol, 2014, 15(8):509-524.
[15] Théry C. Exosomes,secreted vesicles and intercellular communications [J]. F1000 Biol Rep, 2011, 3(15).
[16] Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall J. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [J]. Nature Cell Biology, 2007, 9(6):654-659.
[17] Kogure T, Lin WL, Yan IK, Braconi C, Patel T. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth [J]. Hepatology, 2011, 54(4):1237-1248.
[18] van Balkom BW, de Jong OG, Smits M et al. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells [J]. Blood, 2013, 121(19):3997-4006, S3991-3915.
[19] Pang W, Su J, Wang Y, Feng H, Dai X, Yuan Y, Chen X, Yao W. Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts [J]. Cancer Sci, 2015, 106(10):1362-1369.
[20] Li L, Li C, Wang S et al. Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype[J]. Cancer Res, 2016, 76(7):1770-1780.
[21] Hsu YL, Hung JY, Chang WA, Lin YS, Pan YC, Tsai PH, Wu CY, Kuo PL. Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1[J]. Oncogene, 2017, 36(34):4929-4942.
[22] Fabbri M, Paone A, Calore F et al. MicroRNAs bind to Toll-like receptors to induce pro- metastatic inflammatory response[J]. Proc Natl Acad Sci USA, 2012, 109(31):E2110-2116.
[23] Ogata-Kawata H, Izumiya M, Kurioka D et al. Circulating exosomal microRNAs as biomarkers of colon cancer[J]. PLoS One, 2014, 9(4):e92921.
[24] Moran VA, Perera RJ, Khalil AM. Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs[J]. Nucleic Acids Res, 2012, 40(14):6391-6400.
[25] 韩奕能. 长链非编码RNA与口腔癌研究进展.[J]. 临床与病理杂志, 2016, 36(9):1450-1456.
[26] Gezer U, Ozgur E, Cetinkaya M, Isin M, Dalay N. Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes[J]. Cell Biol Int, 2014, 38(9):1076-1079.
[27] Ji P, Diederichs S, Wang W et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer[J]. Oncogene, 2003, 22(39):8031-8041.
[28] Han Y, Liu Y, Nie L, Gui Y, Cai Z. Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder[J]. Urology, 2013, 81(1):209 e201-207.
[29] Gupta RA, Shah N, Wang KC et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J]. Nature, 2010, 464(7291):1071-1076.
[30] Hayami S, Kelly JD, Cho HS et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers[J]. Int J Cancer, 2011, 128(3):574-586.
[31] Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G. Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma.[J]. J Cancer Res Clin Oncol, 2013, 139(3):437-445.
[32] Qiu M, Xu Y, Yang X, Wang J, Hu J, Xu L, Yin R. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer[J]. Tumour Biol, 2014, 35(6):5375-5380.
[33] Gibb EA, Enfield KS, Stewart GL et al. Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions[J]. Oral Oncol, 2011, 47(11):1055-1061.
[34] Tang H, Wu Z, Zhang J, Su B. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis[J]. Mol Med Rep, 2013, 7(3):761-766.
Cite This Article
  • APA Style

    Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, et al. (2019). Research Progress of Exosome Non-coding RNA in Cancer. Science Discovery, 7(1), 13-17. https://doi.org/10.11648/j.sd.20190701.13

    Copy | Download

    ACS Style

    Jiajia Jin; Shengrong Wu; Xiaoyan Lu; Zixiao Huang; Mei’e Jia, et al. Research Progress of Exosome Non-coding RNA in Cancer. Sci. Discov. 2019, 7(1), 13-17. doi: 10.11648/j.sd.20190701.13

    Copy | Download

    AMA Style

    Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, et al. Research Progress of Exosome Non-coding RNA in Cancer. Sci Discov. 2019;7(1):13-17. doi: 10.11648/j.sd.20190701.13

    Copy | Download

  • @article{10.11648/j.sd.20190701.13,
      author = {Jiajia Jin and Shengrong Wu and Xiaoyan Lu and Zixiao Huang and Mei’e Jia and Xiangyi He},
      title = {Research Progress of Exosome Non-coding RNA in Cancer},
      journal = {Science Discovery},
      volume = {7},
      number = {1},
      pages = {13-17},
      doi = {10.11648/j.sd.20190701.13},
      url = {https://doi.org/10.11648/j.sd.20190701.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.13},
      abstract = {Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.},
     year = {2019}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Research Progress of Exosome Non-coding RNA in Cancer
    AU  - Jiajia Jin
    AU  - Shengrong Wu
    AU  - Xiaoyan Lu
    AU  - Zixiao Huang
    AU  - Mei’e Jia
    AU  - Xiangyi He
    Y1  - 2019/03/08
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sd.20190701.13
    DO  - 10.11648/j.sd.20190701.13
    T2  - Science Discovery
    JF  - Science Discovery
    JO  - Science Discovery
    SP  - 13
    EP  - 17
    PB  - Science Publishing Group
    SN  - 2331-0650
    UR  - https://doi.org/10.11648/j.sd.20190701.13
    AB  - Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.
    VL  - 7
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • School of Dentistry, Lanzhou University, Lanzhou, P. R. China

  • School of Dentistry, Lanzhou University, Lanzhou, P. R. China

  • School of Dentistry, Lanzhou University, Lanzhou, P. R. China

  • School of Dentistry, Lanzhou University, Lanzhou, P. R. China

  • School of Dentistry, Lanzhou University, Lanzhou, P. R. China

  • School of Dentistry, Lanzhou University, Lanzhou, P. R. China

  • Sections